Copper(I) mediated intramolecular cyclization of 2-(2-amino-phenylethynyl)benzoic and [2-(2-amino-phenylethynyl)phenyl]acetic acid esters: A new synthetic step towards isoindolo[2,1-a]indoles and 5H-indolo[2,1-a]iso-quinolines

We describe herein parallel synthetic routes to isoindolo[2,1-a]indoles and 5H-indolo[2,1-a]isoquinolines from 2-(2-aminophenylethynyl)benzoic acid esters and [2-(2-aminophenylethynyl)phenyl]acetic acid esters, respectively.

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Bibliographic Details
Published inSynlett no. 11; pp. 1603 - 1606
Main Authors Reboredo, FJ, Treus, M, Estevez, JC, Castedo, L, Estevez, RJ
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 02.09.2003
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
NITROGEN-HETEROCYCLES
alkaloids
alkynes
(+-)-CRYPTOWOLINE
cyclizations
2-ALKYNYLANILINES
indoles
PALLADIUM-CATALYZED SYNTHESIS
PHOTOINDUCED REACTIONS
RECENT PROGRESS
1-ACYLINDOLES
DERIVATIVES
RING-CLOSURE
HETEROCYCLIC-COMPOUNDS
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Summary:We describe herein parallel synthetic routes to isoindolo[2,1-a]indoles and 5H-indolo[2,1-a]isoquinolines from 2-(2-aminophenylethynyl)benzoic acid esters and [2-(2-aminophenylethynyl)phenyl]acetic acid esters, respectively.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-2003-40984