Solid-phase construction: high efficiency dendrimer synthesis using AB(3) isocyanate-type monomers

Solid-phase synthesis is an ideal tool for reactions that require high concentrations and excess reagents and forcing chemical conditions. One such chemistry is that required for dendrimer construction. In this paper the synthesis of a series of symmetrical AB(3) isocyanate-type monomers is reported...

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Bibliographic Details
Published inTetrahedron Vol. 59; no. 22; pp. 3945 - 3953
Main Authors Lebreton, S, How, SE, Buchholz, M, Yingyongnarongkul, BE, Bradley, M
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 26.05.2003
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
dendrimers
high-loading
isocyanate
PEPTIDE-SYNTHESIS
solid-phase chemistry
multivalency
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Summary:Solid-phase synthesis is an ideal tool for reactions that require high concentrations and excess reagents and forcing chemical conditions. One such chemistry is that required for dendrimer construction. In this paper the synthesis of a series of symmetrical AB(3) isocyanate-type monomers is reported and used for the preparation of tri-branched dendrimers on the solid-phase. This method not only allows isolable dendrimer but can generate high-loading supports and devices for multivalent presentation. (C) 2003 Elsevier Science Ltd. All rights reserved.
ISSN:0040-4020
DOI:10.1016/S0040-4020(03)00463-0