Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and driti-inflammatory agents

A series of arylthioureas (1), aromatic aldehyde thiosemicarbazones (2) and 5-aryl-2-furfuraldehyde thiosemicarbazones (3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles (4). The newly synthesized...

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Bibliographic Details
Published inEuropean journal of medicinal chemistry Vol. 38; no. 3; pp. 313 - 318
Main Authors Holla, BS, Malini, KV, Rao, BS, Sarojini, BK, Kumari, NS
Format Journal Article
LanguageEnglish
Published PARIS CEDEX 15 Elsevier 01.03.2003
Subjects
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Science & Technology
antibacterial activity
arylfurfuraldehyde thiosemicarbazone
thiazoles
arylaldehydethiosemicarbazone
arylthiourea
anti-inflammatory activity
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Summary:A series of arylthioureas (1), aromatic aldehyde thiosemicarbazones (2) and 5-aryl-2-furfuraldehyde thiosemicarbazones (3) were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, arylidene/5-aryl-2-furfurylidene hydrazinothiazoles (4). The newly synthesized compounds were characterized by IR, H-1-NMR and mass spectral studies. These compounds were also screened for their antibacterial and anti-inflammatory activities. Two of the newly synthesized compounds showed anti-inflammatory activity comparable with that of Ibuprofen. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
ISSN:0223-5234
DOI:10.1016/S0223-5234(02)01447-2