Efficient preparation of imidazol[1,2-b]pyridazines under Swern oxidative conditions

An efficient synthesis of new imidazo[1,2-b]pyridazine derivatives was effected by treating 3,6-dichloropyridazine with various 2-hydroxyethylamines following by imidazole ring formation under Swern oxidative conditions. Some mechanistic aspects of the cyclization step are discussed. (C) 2003 Publis...

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Bibliographic Details
Published inTetrahedron letters Vol. 44; no. 14; pp. 2919 - 2921
Main Authors Raboisson, P, Mekonnen, B, Peet, NP
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 31.03.2003
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Swern
imidazole
ANTICONVULSANT PROPERTIES
ACIDS
SAR
IMIDAZO<1,2-B>PYRIDAZINES
oxidation
cyclization
DERIVATIVES
imidazo[1,2-b]pyridazine
HETEROCYCLIC-COMPOUNDS
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Summary:An efficient synthesis of new imidazo[1,2-b]pyridazine derivatives was effected by treating 3,6-dichloropyridazine with various 2-hydroxyethylamines following by imidazole ring formation under Swern oxidative conditions. Some mechanistic aspects of the cyclization step are discussed. (C) 2003 Published by Elsevier Science Ltd.
ISSN:0040-4039
DOI:10.1016/S0040-4039(03)00426-X