Norditerpenoid alkaloids from Consolida orientalis and complete H-1 and C-13 NMR signal assignments of some lycoctonine-type alkaloids

A new norditerpene alkaloid was isolated, 18-demethylpubescenine (1), in addition to four known compounds, 14-demethyltuguaconitine (2), takaosamine (3), gigactonine (4), and delcosine (5), from fresh, whole plants of Consolida orientalis. The structure of 1 was established by spectroscopic methods,...

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Bibliographic Details
Published inJournal of natural products (Washington, D.C.) Vol. 65; no. 7; pp. 1069 - 1072
Main Authors Hohmann, J, Forgo, P, Hajdu, Z, Varga, E, Mathe
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 01.07.2002
Subjects
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Plant Sciences
Science & Technology
DITERPENOID ALKALOIDS
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Summary:A new norditerpene alkaloid was isolated, 18-demethylpubescenine (1), in addition to four known compounds, 14-demethyltuguaconitine (2), takaosamine (3), gigactonine (4), and delcosine (5), from fresh, whole plants of Consolida orientalis. The structure of 1 was established by spectroscopic methods, including various 2D NMR techniques and HRESIMS. As a result of a detailed NMR study, complete H-1 NMR chemical shift assignments for alkaloids 1-5 are presented herein, and some C-13 NMR signal assignments for 2-4 have been revised.
ISSN:0163-3864
1520-6025
DOI:10.1021/np020026z