H-1 and C-13 NMR spectral characterization of some antimalarial in vitro 2,4-diamino-10-methylpyrimido[4,5-b]-5-quinolone derivatives

We report the H-1 NMR and C-13 NMR chemical shifts and J(H,H), J(H,F) and J(C,F) coupling constants of 13 2,4-diamino-10-methylpyrimido[4,5-b]-5-quinolone derivatives, some of them with moderate activity against Plasmodium falciparum in vitro. They were characterized and assigned on the basis of H-1...

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Published inMagnetic resonance in chemistry Vol. 40; no. 7; pp. 477 - 479
Main Authors Charris, JE, Dominguez, JN, Gamboa, N, Angel, J, Pina, N, Guerra, M, Michelena, E, Lopez, SE
Format Journal Article
LanguageEnglish
Published W SUSSEX Wiley 01.07.2002
Subjects
Chemistry
Chemistry, Multidisciplinary
Chemistry, Physical
Physical Sciences
Science & Technology
Spectroscopy
Technology
NMR
IN-VITRO
H-1 NMR
antimalarials
QUINOLONE DERIVATIVES
quinolones
C-13 NMR
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Summary:We report the H-1 NMR and C-13 NMR chemical shifts and J(H,H), J(H,F) and J(C,F) coupling constants of 13 2,4-diamino-10-methylpyrimido[4,5-b]-5-quinolone derivatives, some of them with moderate activity against Plasmodium falciparum in vitro. They were characterized and assigned on the basis of H-1, C-13 and C-13-H-1 (short- and long-range) correlated spectra. Copyright (C) 2002 John Wiley Sons, Ltd.
ISSN:0749-1581
DOI:10.1002/mrc.1024