Health economic analysis and medical cost analysis of children with severe hepatitis B in China: A retrospective study from 2016 to 2022

• Published in: 中华医学杂志英文版 Vol. 138; no. 5; pp. 562 - 567
• Main Authors: Shan Qijun, Ma Xudong, Chen Yujie, Zhou Guanghua, Gao Sifa, Sun Jialu, Guo Fuping, Zhang Feng, Ma Dandan, Sun Guoqiang, Zhu Wen, Meng Xiaoyang, Ruan Guiren, Zhang Yuelun, Tan Xutong, Liu Dawei, Wang Yi, Yin Chang, Zhou Xiang
• Format: Journal Article
• Language: Chinese
• Published: Information Center Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China%Department of Medical Administration, National Health Commission of the People’s Republic of China, Beijing 100044, China%Department of Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China%Department of Information Technology, Center of Statistics and Health Informatics, National Health Commission of People’s Republic of China, Beijing 100044, China%National Institute of Hospital Administration, National Health Commission of the People’s Republic of China, Beijing 100044, China%Department of Infectious Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China%Medical Research Center, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China%Medical Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China%Department of Medical Records and Collaborating Center for the WHO Family of International Classifications in China, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China 2025
• Subjects: Pediatrics; Liver failure; Disease progression; Spatial analysis; Hospitalization; Gross domestic product; Hepatitis B
• ISSN: 0366-6999
• DOI: 10.1097/CM9.0000000000002987

Background::Hepatitis B poses a heavy burden for children in China, however, the national studies on the distributional characteristics and health care costs of children with severe hepatitis B is still lacking. This study aimed to analyze the disease characteristics, health economic effects, and medical cost for children with severe hepatitis B in China.Methods::Based on patient information in the Hospital Quality Monitoring System, cases with severe hepatitis B were divided into four groups according to age, and the etiology and symptoms of each group were quantified. The cost of hospitalization was calculated for cases with different disease processes, and severity of disease. The spatial aggregation of cases and the relationship with health economic factors were analyzed by Moran’s I analysis. Results::The total number of children discharged with hepatitis B from January 2016 to April 2022 was 1603, with an average age of 10.5 years. Liver failure cases accounted for 43.48% (697/1603) of total cases and c