Long-term effect of a large dose of iodinated contrast in patients with mild thyroid dysfunction: a prospective cohort study

• Published in: 中华医学杂志英文版 Vol. 136; no. 17; pp. 2044 - 2049
• Main Authors: Si Hailong, Chen Kangyin, Qin Qin, Liu Yuanyuan, Zhao Bingrang
• Format: Journal Article
• Language: Chinese
• Published: Department of Cardiology, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China%Department of Cardiovascular Disease, Tianjin Chest Hospital, Tianjin 300051, China%Tianjin Institute of Cardiovascular Diseases, Tianjin Chest Hospital, Tianjin 300051, China%Comprehensive Disease Center, Tianjin Chest Hospital, Tianjin 300051, China 2023
• Subjects: Stable angina pectoris; Subclinical thyroid dysfunction; Non-thyroidal illness; Low T3; Iodinated contrast agents; Coronary heart disease
• ISSN: 0366-6999
• DOI: 10.1097/CM9.0000000000002260

Background::More than 75 million procedures with intravascular iodine-based contrast media (ICM) are performed worldwide every year, and some patients undergoing these procedures do not have normal thyroid function. The long-term effects of ICM in patients with mild thyroid dysfunction (TD) are unclear.Methods::This prospective cohort study was conducted in China. Patients with stable angina pectoris with total triiodothyronine (TT3) reduction, normal thyroid-stimulating hormone, and reverse triiodothyronine (rT3) were enrolled and divided into high-dose (≥100 mL ICM) and low-dose groups (<100 mL ICM). We dynamically investigated the trends in thyroid function, rT3, and thyroid antibodies one year after ICM exposure.Results::A total of 154 patients completed 6 months of follow-up and 149 completed 1 year of follow-up. Thyroglobulin antibody (TGAB) levels were elevated in 41 (26.6%) patients before ICM exposure, 11 (7.1%) of whom also had elevated thyroid peroxidase antibody levels. Transient subclinical TD oc