Study on Effect of Baoyuan Qiangshen (保元强肾) Capsule No. Ⅱ on Tubular Interstitial Injury in Chronic Renal Failure Patients

• Published in: 中国中西医结合杂志(英文版) Vol. 7; no. 3; pp. 175 - 179
• Main Authors: ZHU Pi-jiang, WEI Xian-jin, ZHAO Wei-bing, ZHAO Hua, TIAN Jun-min, QIU Jian-jun
• Format: Journal Article
• Language: English
• Published: Jiangsu Provincial TCM-WM Center of Nephropathy, Zhenjiang 2001
• ISSN: 1672-0415

R28; Objective: To explore the protective effect of Baoyuan Qiangshen Capsule No. Ⅱ (BYQS) and its mechanism in treating chronic renal failure (CRF). Methods: Sixty CRF patients were divided into 2 groups randomly, the treated group used BYQS combined with Lotensin and the control group administered with essential amino acid combined with Lotensin. Changes of renal functions and tubular labelled proteins were observed. Results: The markedly effective rate and total effective rate of the treated group were 63.3% and 93.3% respectively, and those of the control group were 30.0% and 56.7% respectively, the effect of the treated group was obviously better than that of the control group (P<0.01). In the treated group after medication, blood urea nitrogen, serum creatinine and clearance rate of creatinine were improved significantly (P<0.01), while Tamm-Horfau protein increased significantly (P<0.01). Conclusion: BYQS could alleviate tubular interstitial injury significantly so as to improve the renal function and enhance the effective rate in treating CRF.