Melatonin lowers edema after spinal cord injur y

Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal...

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Bibliographic Details
Published in中国神经再生研究（英文版） no. 24; pp. 2205 - 2210
Main Authors Cheng Li, Xiao Chen, Suchi Qiao, Xinwei Liu, Chang Liu, Degang Zhu, Jiacan Su, Zhiwei Wang
Format Journal Article
LanguageEnglish
Published Department of 0rthopedic Surgery, Changhai Hospital, the Second Military Medical University, Shanghai, China%Laboratory of Severe and War-Related Trauma Center, General Hospital of Shenyang Military Area Command of Chinese PLA, Shenyang, Liaoning Province, China 2014
Subjects
spinal cord injury
western blot assay
neural regeneration
edema
nerve regeneration
immunohistochemistry
melatonin
aquaporin
glial fibrillary acidic protein
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Summary:Melatonin has been shown to diminish edema in rats. Melatonin can be used to treat spinal cord injury. This study presumed that melatonin could relieve spinal cord edema and examined how it might act. Our experiments found that melatonin (100 mg/kg, i.p.) could reduce the water content of the spinal cord, and suppress the expression of aquaporin-4 and glial ifbrillary acidic protein after spinal cord injury. This suggests that the mechanism by which melatonin alleviates the damage to the spinal cord by edema might be related to the expression of aquaporin-4 and glial ifbrillary acidic protein.
ISSN:1673-5374
DOI:10.4103/1673-5374.147954