FAS-670A/G andFAS-1377G/A polymorphism in cell death pathway geneFAS and human male infertility

Objective:To study the role and association of functional variations present inFAS gene with idiopathic male infertility.Methods:The case-control study comprised of two groups:160 idiopathic infertile nonobstructive azoospermia patients and200 fertile healthy control men. Genotyping for single-nucle...

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Published in亚太生殖杂志（英文版） no. 3; pp. 183 - 186
Main Authors Deepika Jaiswal, Udai Shankar Dwivedi, Neeraj Kumar Agrawal, Sameer Trivedi, Kiran Singh
Format Journal Article
LanguageEnglish
Published Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi, India%Department of Urology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India%Department of Endocrinology and Metabolism, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India 2012
Subjects
Male infertility
FAS-670
FAS-1377
Polymorphism
Apoptosis
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Summary:Objective:To study the role and association of functional variations present inFAS gene with idiopathic male infertility.Methods:The case-control study comprised of two groups:160 idiopathic infertile nonobstructive azoospermia patients and200 fertile healthy control men. Genotyping for single-nucleotide polymorphism ofFAS-670A/G(rs1800682) andFAS-1377G/A (rs2234767) was done byPCR-RFLP method.DNA sequencing was used to ascertainPCR-RFLP results.ForFAS-670A/G andFAS-1377G/A functional polymorphism, allele and genotype distribution were evaluated usingChi-square test.Results:Allele and genotype distribution did not differ significantly between patients and controls forFAS-670A/G andFAS-1377 G/A.Conclusions:Human male infertility is a complex disorder and thus other genetic or environmental factors may be contributing to the complex etiology.
ISSN:2305-0500