Antidiabetic, antihyperlipidemic and antioxidant potential of methanol extract ofTectona grandis flowers in streptozotocin induced diabetic rats

• Published in: 亚太热带医药杂志（英文版） no. 8; pp. 624 - 631
• Main Authors: Subramaniam Ramachandran, Aiyalu Rajasekaran, KT Manisenthil Kumar
• Format: Journal Article
• Language: English
• Published: Department of Pharmacology, KMCH College of Pharmacy, Coimbatore - 641 048, Tamil Nadu, India%Department of Pharmaceutical Chemistry, KMCH College of Pharmacy, Coimbatore - 641 048, Tamil Nadu, India 2011
• Subjects: Lipid profile; Diabetes; Tectona grandis; Antioxidant; Streptozotocin
• ISSN: 1995-7645; 2352-4146

Objective:To investigate antidiabetic, antihyperlipidemic and antioxidant activity of methanol extract ofTectona grandis (T. grandis) flowers(METGF)in streptozotocin (STZ) induced diabetic rats to supports its traditional use.Methods: Acute toxicity study of METGF was carried out in rat to determine its dose for the antidiabetic study. Oral glucose tolerance test(OGTT) was performed to evaluateMETGF effect on elevated blood glucose level. Diabetes was induced in rats by administration ofSTZ(60 mg/kg, ip.) and it was confirmed 72 h after induction.METGF was orally given to the diabetic rats up to28 days and blood glucose level were estimated each week. On28 day of the experiment, diabetic rats were sacrificed after the blood collection for the biochemical parameters analysis and liver, kidney was collected to determine antioxidants levels.Results:In acute toxicity,METGFdid not show toxicity and death up to a dose 2 000mg/kg in rats. Administration ofMETGF 100 and200mg/kg significantly (P<0.001) reduced blood glucose levels inOGTTand STZ-induced diabetic rats. Both doses ofMETGF treatment significantly (P<0.001, P<0.01 andP<0.05) increased body weight, serum insulin, haemoglobin (Hb) and total protein levels in diabetic rats. Also,MEGTF treatment reduced elevated glycosylated haemoglobin(HbA1c) and other biochemical parameters levels significantly (P<0.001) in diabetic rats. Altered lipid profiles and antioxidants levels were reversed to near normal in diabetic rats treated withMETGF. Conclusions: These results concluded that METGF possesses antidiabetic, antihyperglycemic and antioxidant activity which supports its traditional use.