The evolving role of Fourier-transform mid-infrared spectroscopy in geneticimprovement of dairy cattle

• Published in: 畜牧与生物技术杂志（英文版） Vol. 11; no. 3; pp. 626 - 638
• Main Authors: K. M. Tiplady, T. J. Lopdell, M. D. Littlejohn, D. J. Garrick
• Format: Journal Article
• Language: English
• Published: Research and Development, Livestock Improvement Corporation, Private Bag 3016, Hamilton 3240, New Zealand 2020; School of Agriculture, Massey University, Ruakura, Hamilton 3240, New Zealand%Research and Development, Livestock Improvement Corporation, Private Bag 3016, Hamilton 3240, New Zealand%School of Agriculture, Massey University, Ruakura, Hamilton 3240, New Zealand
• Subjects: Cattle breeding genetics; Trait prediction; Bovine milk; Fourier-transform infrared spectroscopy
• ISSN: 1674-9782

Over the last 100 years, significant advances have been made in the characterisation of milk composition for dairy cattle improvement programs. Technological progress has enabled a shift from labour intensive, on-farm collection and processing of samples that assess yield and fat levels in milk, to large-scale processing of samples throughcentralised laboratories, with the scope extended to include quantification of other traits. Fourier-transform mid-infrared (FT-MIR) spectroscopy has had a significant role in the transformation of milk composition phenotyping, with spectral-based predictions of major milk components already being widely used in milk payment and animal evaluation systems globally. Increasingly, there is interest in analysing the individual FT-MIR wavenumbers, and in utilising the FT-MIR data to predict other novel traits of importance to breeding programs. This includes traits related to the nutritional value of milk, the processability of milk into products such as cheese, and traits relevant to animal health and the environment. The ability to successfully incorporate these traits into breeding programs is dependent on the heritability of the FT-MIR predicted traits, and the genetic correlations between the FT-MIR predicted and actual trait values. Linking FT-MIR predicted traits to the underlying mutations responsible for their variation can be difficult because the phenotypic expression of these traits are a function of a diverse range of molecular and biological mechanisms that can obscure their genetic basis. The individual FT-MIR wavenumbers give insights into the chemical composition of milk and provide an additional layer of granularity that may assist with establishing causal links between the genome and observed phenotypes. Additionally, there are other molecular phenotypes such as those related to the metabolome, chromatin accessibility, and RNA editing that could improve our understanding of the underlying biological systems controlling traits of interest. Here we review topics of importance to phenotyping and genetic applications of FT-MIR spectra datasets, and discuss opportunities for consolidating FT-MIR datasets with other genomic and molecular data sources to improve future dairy cattle breeding programs.