The relationship between sarcopenia, multidimensional frailty, and malnutrition cluster and long-term mortality in hospitalized patients with cirrhosis

Aim::Sarcopenia, multidimensional frailty, and malnutrition represent common debilitating conditions in the context of cirrhosis, linked to a variety of dismal outcomes. We aimed to clarify their overlap and cumulative impact on long-term mortality in hospitalized patients with cirrhosis.Methods::Co...

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Published in门静脉高压与肝硬化（英文） Vol. 2; no. 2; pp. 51 - 60
Main Authors Guo Gaoyue, Wang Han, Yang Wanting, Li Chaoqun, Zhao Xingliang, Fan Xiaofei, Hui Yangyang, Cui Binxin, Wang Xiaoyu, Zhang Xuqian, Jiang Kui, Sun Chao
Format Journal Article
LanguageChinese
Published Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China%Department of Health Management, Tianjin Hospital, Tianjin, China%Department of Internal Medicine, Tianjin Hexi Hospital, Tianjin, China%Department of Gastroenterology, Tianjin Medical University General Hospital Airport Hospital, Tianjin, China%Department of Gastroenterology and Hepatology, China Aerospace Science & Industry Corporation 731 Hospital, Beijing, China 2023
Subjects
frailty
malnutrition
comorbidity
mortality
liver cirrhosis
sarcopenia
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ISSN2770-5838
DOI10.1002/poh2.50

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Summary:Aim::Sarcopenia, multidimensional frailty, and malnutrition represent common debilitating conditions in the context of cirrhosis, linked to a variety of dismal outcomes. We aimed to clarify their overlap and cumulative impact on long-term mortality in hospitalized patients with cirrhosis.Methods::Consecutive patients with cirrhosis were prospectively recruited from January 2018 to December 2020. The diagnosis of sarcopenia, multidimensional frailty, and malnutrition was standardized according to the consensus definition and our well-documented criteria. The prevalence of the respective debilitating condition and the concurrence of this comorbidity were calculated.Results::In total, 253 patients with cirrhosis aged 64 years with a female predominance (52.4%) were recruited. Sarcopenia was present in 20.9% (53/253), multidimensional frailty in 12.6% (32/253), and malnutrition in 44.7% (113/253) of the entire cohort. Approximately half of the patients had at least one debilitating condition (127/253). Sarcopenia
ISSN:2770-5838
DOI:10.1002/poh2.50