The ameliorative effects ofAverroha carambola on humoral response to sheep erythrocytes in non-treated and cyclophosphamide-immunocompromised mice

• Published in: 急性病杂志（英文版） no. 2; pp. 115 - 123
• Main Authors: Shadma Wahab, Arshad Hussain, Md Parwez Ahmad, Aliza Rizvi, Md Faruque Ahmad, Alaul Hasan Abad Farooqui
• Format: Journal Article
• Language: English
• Published: Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India%Department of Clinical Nutrition, Jazan University, Jazan, Kingdom of Saudi Arabia KSA, Saudi Arabia%Department of Biotechnology, Integral University Lucknow, Uttar Pradesh, India 2014
• Subjects: Oxidative stress; Cytokine production; Immunomodulation; Cyclophasphamide; HPTLC
• ISSN: 2221-6189; 2221-6189
• DOI: 10.1016/S2221-6189(14)60027-5

Objective:To evaluated immunomodulatory and antioxidant activity of the methanol extract ofAverrhoa carambola(A. carambola) leaves in mice.Methods:The assessment of immunomodulatory activity on specific and non-specific immunity was studied by administration of test extract by oral feeding canula to the test groups.Hemagglutinating antibody(HA) titer, delayed type of hypersensitivity(DTH) response, hematological profile(Hb,WBC,RBC), lipid per oxidation(LPO), reduced glutathione(GSH), superoxide dismutase(SOD), catalase(CAT) were determined by in vivo experiments.Results:The evaluation of immunomodulatory potential of A. carambola(800 and1200 mg/kg, p.o.) evoked a dose-dependent increase in antibody titer values andDTH reaction induced bySRBC was also found significant(P<0.001).Also it caused increase in hematological profile,GSH,SOD,CAT activity and significantly decreasedLPO levels in cyclophosphamide-induced immunosuppressed mice.Result shows that the extract treated animals showed up regulation of(IL-6 andTNF-α) cytokines.Conclusions:Immunomodulators are being used as an adjuvant in conditions of immunodeficiency in cancer and to a limited extent in acquired immunodeficiency syndrome.The results obtained in this study indicate that A. carambola possesses potential immunomodulatory and antioxidant activity.