Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false?negative results

Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Health Organization (WHO) product testing summary and discuss the causes of false-negative (FN...

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Published in军事医学研究（英文版） Vol. 9; no. 3; pp. 379 - 381
Main Authors Biao Xu, Bo Tu, Fang Chu, Mohamed Jalloh, Jin?Song Mu, Jun?Jie Zheng, Wei?Wei Chen
Format Journal Article
LanguageEnglish
Published Chinese Military Medical Expert Group in Sierra Leone,the Fifth Medical Center of Chinese PLA General Hospital,Beijing 100039,China%the 34Th Military Hospital,Wilberforce Barracks,Freetown,Sierra Leone 2022
Subjects
Rapid diagnostic tests
False-negative results
Malaria
WHO product testing
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Summary:Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Health Organization (WHO) product testing summary and discuss the causes of false-negative (FN) results with a focus on low parasite density, improper RDT storage, operation and interpretation, and Plasmodium falciparum with a pfhrp2/3 gene deletion. The results demonstrated that the malaria RDTs currently commercially available might cause FN results in practice.
ISSN:2095-7467