Effect of ethanolic extract of Pericampylus glaucus (Lam) Merr on biochemical parameters in Sprague-Dawley rats with high fats diets

• Published in: 海岸生命医学杂志(英文版) Vol. 5; no. 5; pp. 219 - 223
• Main Authors: Kifayatullah Muhammad, Mustapha Mohd Shahimi, AravinthVijay Jesuraj, Sengupta Pinaki, Khan Muhammad Shahid, Kaleemullah
• Format: Journal Article
• Language: English
• Published: Faculty of Pharmacy, Lincoln University College, Malaysia%Department of Pharmaceutical Technology, Islamic International University, Malaysia%Faculty of Business and Management Sciences, Limkokwing University, Malaysia%Faculty of Civil and Environmental Engineering, UTHM Batu Pahat, Malaysia 2017
• Subjects: Pericampylus glaucus (Lam) Merr; Biochemical parameters; Ethanolic extract; Male Sprague-Dawley rats
• ISSN: 2309-5288

Objective: To evaluate the effect of ethanolic extract of Pericampylus glaucus (Lam) Merr (P. glaucus) on biochemical parameters in high fats diets treated rats. Methods: The effect of P. glaucus extract on biochemical parameters was studied in male Sprague Dawley rats. The high-fat diets along with standard normal laboratory rat's diets were given for a period of 28 days along with ethanolic extract of P. glaucus and standard drug. The standard group was treated with simvastatin at dose of 80 mg/kg and the tested groups were treated with ethanol extract of P. glaucus at 400, 600 and 800 mg/kg daily for 28 days of the experiment. The weight of animals in each group was measured weekly and the effect of extract and standard on serum lipids profile was evaluated at the end of the study. Results: The results showed that the ethanolic extract of P. glaucus at different doses of 400, 600 and 800 mg/kg and standard drug induced a significant reduction in the body weight (P< 0.001), total cholesterol, triglycerides (TG), low density lipoproteins (LDL) and uric acid levels and increase (P < 0.001) in high density lipoproteins (HDL) as compared to untreated hyperlipidemic group. Conclusions: The present work indicates that the ethanolic extract significantly suppressed the biochemical parameters in high fats diet treated animals, suggesting the antihyperlipidemic potential of P. glaucus.