67例胃腺瘤临床病理特征及免疫表型分析

R73; Objective: The aim of this study was to investigate the clinicopathologic features of gastric adenoma. Methods:Sixty-seven cases of adenoma diagnosis of gastric biopsy specimens using light microscopy, immunohistochemistry, and follow-up methods were studied. Results: Histopathology of gastric...

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Bibliographic Details
Published in中德临床肿瘤学杂志（英文版） Vol. 9; no. 9; pp. 511 - 515
Format Journal Article
LanguageChinese
Published Department of Laboratory,The 150 Centre Hospital of Chinese PLA,Luoyang 471031,China 2010
Subjects
adenoma
pathology
gastric biopsy
immunohistochemistry
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ISSN1610-1979
DOI10.1007/s10330-010-0665-7

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Summary:R73; Objective: The aim of this study was to investigate the clinicopathologic features of gastric adenoma. Methods:Sixty-seven cases of adenoma diagnosis of gastric biopsy specimens using light microscopy, immunohistochemistry, and follow-up methods were studied. Results: Histopathology of gastric adenoma characteristics: nuclear anaplasia, showing increase of nuclear volume and irregular, and the emergence of one or more nucleoli, mitotic ≤ 2/10 high power field (HPF).Structural changes in the gland: adenoma of the duct much more consistent, sometimes the size of the gland and irregular contour, might be associated with intestinal metaplasia. Increased significantly when the nuclear volume, mitotic ＞ 2/10 HPF,irregular gland distortion, branched structures, suggesting the development of adenomas. Immunophenotype: tumor-associated carbohydrate antigens had a higher expression; adenomatous polyposis coli gene (APC) and carcinoembryonic antigen (CEA) expression of closely related with the formation of adenoma.
ISSN:1610-1979
DOI:10.1007/s10330-010-0665-7