电致孔经皮给药:表面活性剂对孔道存在时间和药物传输的影响

• Published in: 中国化学工程学报（英文版） Vol. 15; no. 3; pp. 397 - 402
• Main Authors: 蒋国强, 朱德权, 咎佳, 丁富新
• Format: Journal Article
• Language: Chinese
• Published: Department of Chemical Engineering, Tsinghua University, Beijing 100084, China 2007
• Subjects: skin electroporation; aqueous pathway; transdermal drug delivery; surfactant
• ISSN: 1004-9541; 2210-321X

TQ46; Electroporation creates aqueous pathways by short high-voltage pulses resulting in a transient permeabilization of stratum corneum and an increase in the transdermal delivery rate.However the aqueous pathways will reseal after pulsing, which leads to the rapid drop of transdermal flux.In the present study, the surfactants were added to the donor solution to hinder the shrinkage and resealing of the electropore, and to prolong the lifetime of the aqueous pathways with the consideration that the surfactants could reduce the surface energy of the electropore.These effects of surfactants were demonstrated by the dynamic electrical resistance of the skin and the fluorescent imaging of the local transport regions.Piroxicam (FIX) was transported percutaneously in the presence of surfactants in vitro.Owing to the longer lifetime of aqueous pathways, together with the promotion of FIX availability at the barrier exterior and the improvement in the partition of FIX into the aqueous pathways, the presence of surfa