Four independent molecular prion protein parameters for discriminating new cases of C, L, and H BSE in cattle

In anticipation of the emergence of more variants of bovine spongiform encephalopathy (BSE), a semiquantitative display of the following four independent molecular diagnostic prion parameters was designed: N terminus, proteinase K (PK) resistance, glycoprofile, and mixed population. One H BSE case,...

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Bibliographic Details
Published inJournal of clinical microbiology Vol. 49; no. 8
Main Authors Langeveld, J.P.M, Erkens, J.H.F, Rammel, I, Jacobs, J.G, Davidse, A, Zijderveld, F.G., van, Bossers, A, Schildorfer, H
Format Journal Article
Published 2011
Subjects
atypical bse
diseases
great-britain
identification
monoclonal-antibodies
prpsc
rich
similarities
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Summary:In anticipation of the emergence of more variants of bovine spongiform encephalopathy (BSE), a semiquantitative display of the following four independent molecular diagnostic prion parameters was designed: N terminus, proteinase K (PK) resistance, glycoprofile, and mixed population. One H BSE case, three L BSE cases, six C BSE cases, and one unusual classical BSE (C BSE) case are reported.
ISSN:0095-1137
1098-660X