Evaluation of vaccination strategies against infection with feline immunodeficiency virus (FIV) based on recombinant viral vectors expressing FIV Rev and OrfA

In recent years it has become clear that cell-mediated immunity is playing a role in the control of lentivirus infections. In particular, cytotoxic T lymphocyte responses have been associated with improved outcome of infection, especially those directed against the regulatory proteins like Rev and T...

Full description

Saved in:
Bibliographic Details
Published inVeterinary immunology and immunopathology Vol. 126; pp. 3 - 4
Main Authors Huisman, W, Schrauwen, E.J.A, Tijhaar, E, Süzer, Y, Pas, S.D, Amerongen, G., van, Sutter, G, Rimmelzwaan, G.F, Osterhaus, A.D.M.E
Format Journal Article
Published 2008
Subjects
89.6p challenge
animal-model
cytotoxic t-lymphocytes
envelope glycoprotein
protective immunity
replication
rhesus macaques
semliki-forest-virus
subunit vaccines
tat protein
Online AccessGet full text

Cover

More Information
Summary:In recent years it has become clear that cell-mediated immunity is playing a role in the control of lentivirus infections. In particular, cytotoxic T lymphocyte responses have been associated with improved outcome of infection, especially those directed against the regulatory proteins like Rev and Tat, which are expressed early after infection. Therefore, there is considerable interest in lentiviral vaccine candidates that can induce these types of immune responses. In the present study, we describe the construction and characterisation of expression vectors based on recombinant Semliki Forest virus system and modified vaccinia virus Ankara for the expression of feline immunodeficiency virus (FIV) accessory proteins Rev and OrfA. These recombinant viral vectors were used to immunize cats using a prime-boost regimen and the protective efficacy of this vaccination strategy was assessed after challenge infection of immunized cats with FIV.
ISSN:0165-2427
1873-2534