Macrocyclic compounds for inhibition of tumor necrosis factor alpha

Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and ast...

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Bibliographic Details
Main Authors Lee, Jinbo, Bond, Julian F, Terrett, Nicholas, Favaloro, Jr, Frank G, Wang, Daniel, Briggs, Timothy F, Seigal, Benjamin Adam, Sun, Wei-Chuan, Hale, Stephen P
Format Patent
LanguageEnglish
Published 25.12.2012
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Summary:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.