Fused thiophene derivatives as kinase inhibitors

A series of 5,6-dihydro-1-benzothiophen-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of...

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Main Authors Alexander, Rikki Peter, Bailey, Stuart, Brand, Stephen, Brookings, Daniel Christopher, Brown, Julien Alistair, Haughan, Alan Findlay, Kinsella, Natasha, Lowe, Christopher, Mack, Stephen Robert, Pitt, William Ross, Richard, Marianna Dilani, Sharpe, Andrew, Tait, Laura Jane
Format Patent
LanguageEnglish
Published 04.12.2012
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Summary:A series of 5,6-dihydro-1-benzothiophen-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.