Preparation of 10-keto morphinans by benzylic oxidation

The present invention provides processes for the preparation of 10-keto and/or 10-hydroxy morphinans. In particular, the invention provides to processes for preparing a 10-keto morphinan by chromium-catalyzed benzylic oxidation of a morphinan with a periodic acid.

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Bibliographic Details
Main Authors Sun, Hang, Johnson, Jr, John E, Fenton, Ricky L, Dorn, Sarah M
Format Patent
LanguageEnglish
Published 20.11.2012
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Summary:The present invention provides processes for the preparation of 10-keto and/or 10-hydroxy morphinans. In particular, the invention provides to processes for preparing a 10-keto morphinan by chromium-catalyzed benzylic oxidation of a morphinan with a periodic acid.