open reading frames encoding polypeptide antigens and uses thereof

• Main Authors: Zagursky, Robert John, Masi, Amy Wadhams, Green, Bruce Arthur, Chakravarti, Deb Narayan, Russell, David Parrish, Wooters, Joseph Lawrence
• Format: Patent
• Language: English
• Published: 14.08.2012

Streptococcus pneumoniaeStreptococcus pneumoniaeStreptococcus pneumoniae Streptococcus pneumoniae Streptococcus pneumoniae Streptococcus pneumoniaeStreptococcus pneumoniaeStreptococcus pneumoniae. The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of , wherein the open reading frames encode polypeptides that are surface localized on . Thus, the invention relates to open reading frames that encode polypeptide antigens, polypeptides, preferably antigenic polypeptides, encoded by the open reading frames, vectors comprising open reading frame sequences and cells or animals transformed with these vectors. The invention relates also to methods of detecting these nucleic acids or polypeptides and kits for diagnosing infection. The invention finally relates to pharmaceutical compositions, in particular immunogenic compositions, for the prevention and/or treatment of bacterial infection, in particular infections with . In particular embodiments, the immunogenic compositions are used for the treatment or prevention of systemic diseases which are induced or exacerbated by . In other embodiments, the immunogenic compositions are used for the treatment or prevention of non-systemic diseases, particularly of the otitis media, which are induced or exacerbated by