Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers

A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the con...

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Main Authors Babcock, Walter C, Curatolo, William J, Friesen, Dwayne T, Ketner, Rodney J, Lo, Julian B, Nightingale, James A. S, Shanker, Ravi M, West, James B
Format Patent
LanguageEnglish
Published 07.08.2012
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Abstract A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
AbstractList A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
Author Ketner, Rodney J
Shanker, Ravi M
Babcock, Walter C
Curatolo, William J
Nightingale, James A. S
Lo, Julian B
Friesen, Dwayne T
West, James B
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