Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers

A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the con...

Full description

Saved in:
Bibliographic Details
Main Authors Babcock, Walter C, Curatolo, William J, Friesen, Dwayne T, Ketner, Rodney J, Lo, Julian B, Nightingale, James A. S, Shanker, Ravi M, West, James B
Format Patent
LanguageEnglish
Published 07.08.2012
Online AccessGet full text

Cover

More Information
Summary:A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.