Cyanine dyes and methods of use

The present invention provides for cyanine dyes as near IR quenchers. The cyanine dyes have absorption wavelengths in the near-infrared region of about 650-900 nm and are essentially non-fluorescent. The dyes of the invention have at least one linking group. The present invention also provides subst...

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Bibliographic Details
Main Authors Peng, Xinzhan, Xu, Xinshe, Draney, Daniel R, Little, Garrick M, Chen, Jiyan, Volcheck, William M, Prescott, Charles
Format Patent
LanguageEnglish
Published 24.07.2012
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Summary:The present invention provides for cyanine dyes as near IR quenchers. The cyanine dyes have absorption wavelengths in the near-infrared region of about 650-900 nm and are essentially non-fluorescent. The dyes of the invention have at least one linking group. The present invention also provides substantially non-fluorescent, NIR probes. Biological assays based on these novel, substantially non-fluorescent, NIR probes are also provided.