Methods of whole genome analysis

Methods are provided for ascertaining the sequence of a genomic DNA sample by nicking the DNA sample with a restriction nicking enzyme, followed by nick translation with labeled nucleotides, such that the labeled nucleotides can be quantified and compared to a known, reference genome.

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Bibliographic Details
Main Authors Schwartz, David C, Potamousis, Konstantinos D, Zhou, Shiguo, Goldstein, Steven J, Newton, Michael A, Runnheim, Rodney A, Forrest, Daniel K, Churas, Christopher P
Format Patent
LanguageEnglish
Published 17.07.2012
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Summary:Methods are provided for ascertaining the sequence of a genomic DNA sample by nicking the DNA sample with a restriction nicking enzyme, followed by nick translation with labeled nucleotides, such that the labeled nucleotides can be quantified and compared to a known, reference genome.