Nitrogenated fused ring derivative, pharmaceutical composition comprising the same, and use of the same for medical purposes

A B 11234234C 22 [Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like.[Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) wh...

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Bibliographic Details
Main Authors Yonekubo, Shigeru, Miyagi, Takashi, Ohno, Kohsuke, Kambara, Mikie, Fushimi, Nobuhiko
Format Patent
LanguageEnglish
Published 10.07.2012
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Summary:A B 11234234C 22 [Purpose] The present invention provides compounds useful as agents for the prevention or treatment of a sex hormone-dependent disease or the like.[Solution] The present invention provides nitrogen-containing fused ring derivatives represented by the following general formula (I) which has a GnRH antagonistic activity, prodrugs, salts, pharmaceutical compositions containing the same, medicinal uses thereof and the like. In the formula (I), rings A and B are independently aryl or heteroaryl; Rand Rare independently halogen, cyano, alkyl, alkylsulfonyl, -OW, -SW, -COW, -NWW, -SONWW, aryl, etc.; Ris H or alkyl; E is oxygen atom, etc.; U is single bond or alkylene; and X is Y, -CO-Y, -SO-Y, -S-(alkylene)-Y, -O-(alkylene)-Y, -SO-(alkylene)-Y, etc.; Y is Z or amino, etc.; and Z is cycloalkyl, heterocycloalkyl, aryl, heteroaryl, etc.