Endosomolytic polymers

We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inacti...

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Bibliographic Details
Main Authors Rozema, David B, Wakefield, Darren H, Wolff, Jon A, Hagstrom, James E, Ekena, Kirk
Format Patent
LanguageEnglish
Published 03.07.2012
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Summary:We describe pH-sensitive endosomolytic polymers, delivery particles containing pH-sensitive endosomolytic polymers. The described particles are capable of delivering polynucleotides to cells from the peripheral circulation with subsequent release from endosomes. The endosomolytic polymers are inactive outside the cell but disrupt membranes upon exposure to an acidified endosomal compartment.