Spiro-oxindole compounds and their uses as therapeutic agents

1, 2a2b2c2d3a3b3c3d This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, RR, R, R, R, R, R, R, and Rare as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which...

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Main Authors Chafeev, Mikhail, Chakka, Nagasree, Chowdhury, Sultan, Fraser, Robert, Fu, Jianmin, Hou, Duanjie, Hsieh, Tom, Kamboj, Rajender, Liu, Shifeng, Raina, Vandna, Bagherzadeh, Mehran Seid, Sun, Jianyu, Sun, Shaoyi, Sviridov, Serguei
Format Patent
LanguageEnglish
Published 31.01.2012
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Summary:1, 2a2b2c2d3a3b3c3d This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, RR, R, R, R, R, R, R, and Rare as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.