Substituted pyridazines inhibitors of MEK

1278 9Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R, R, R, Rand R, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflamm...

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Bibliographic Details
Main Authors Marlow, Allison L, Wallace, Eli, Seo, Jeongbeob, Lyssikatos, Joseph P, Yang, Hong woon, Blake, James F
Format Patent
LanguageEnglish
Published 24.01.2012
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Summary:1278 9Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R, R, R, Rand R, W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.