Kinase modulators and methods of use

21253321231 The present invention relates to compounds of the Formula (I) and (II) wherein R, R, R-R, m, n, X-X, and Qare defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration...

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Main Authors Anand, Neel K, Blazey, Charles M, Bowles, Owen Joseph, Bussenius, Joerg, Bannen, Lynne Canne, Chan, Diva Sze-Ming, Chen, Baili, Co, Erick Wang, Costanzo, Simona, Defina, Steven Charles, Dubenko, Larisa, Franzini, Maurizio, Huang, Ping, Jammalamadaka, Vasu, Khoury, Richard George, Kim, Moon Hwan, Klein, Rhett Ronald, Le, Donna Tra, Mac, Morrison B, Nuss, John M, Parks, Jason Jevious, Rice, Kenneth D, Tsang, Tsze H, Tsuhako, Amy Lew, Wang, Yong, Xu, Wei
Format Patent
LanguageEnglish
Published 13.12.2011
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Summary:21253321231 The present invention relates to compounds of the Formula (I) and (II) wherein R, R, R-R, m, n, X-X, and Qare defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.