Live, oral vaccine for protection against

Salmonella typhi Shigella dysenteriae Shigella dysenteriae The invention relates to Ty21a comprising core-linked serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs:...

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Bibliographic Details
Main Authors Kopecko, Dennis J, Xu, DeQi
Format Patent
LanguageEnglish
Published 06.12.2011
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Summary:Salmonella typhi Shigella dysenteriae Shigella dysenteriae The invention relates to Ty21a comprising core-linked serotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encoding serotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.