Use of a chromatography substrate for reducing the amount of ADAMTS13 in a solution derived from plasma

An ion-exchange chromatography support for reducing the ADAMTS13 amount present in a plasma-derived solution containing human von Willebrand factor. The support includes a large-pore, vinyl polymer-type resin bearing DEAE groups, and a buffer including trisodium citrate, sodium chloride, calcium chl...

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Bibliographic Details
Main Authors Bridey, Francoise, Schmitthaeusler, Roland
Format Patent
LanguageEnglish
Published 27.09.2011
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Summary:An ion-exchange chromatography support for reducing the ADAMTS13 amount present in a plasma-derived solution containing human von Willebrand factor. The support includes a large-pore, vinyl polymer-type resin bearing DEAE groups, and a buffer including trisodium citrate, sodium chloride, calcium chloride, glycine and lysine.