Process for production of 2,3,4-trifluoro-5-(iodo or bromo)-benzoic acid

The invention provides a process for production of 2,3,4-trifluoro-5-(iodo or bromo)benzoic acid, the process comprising a halogenation step in which direct iodination or bromination of 2,3,4-trifluorobenzoic acid is performed with an iodinating agent or brominating agent in a reaction solvent in th...

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Bibliographic Details
Main Authors Koyano, Hiroshi, Iikura, Hitoshi, Isshiki, Yoshiaki, Kohchi, Yasunori
Format Patent
LanguageEnglish
Published 20.09.2011
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Summary:The invention provides a process for production of 2,3,4-trifluoro-5-(iodo or bromo)benzoic acid, the process comprising a halogenation step in which direct iodination or bromination of 2,3,4-trifluorobenzoic acid is performed with an iodinating agent or brominating agent in a reaction solvent in the presence of an oxidizing agent. According to the invention, there is provided a process for convenient production of 2,3,4-trifluoro-5-(iodo or bromo)benzoic acid in high yield and high purity in a highly regioselective manner.