Methods for the preparation of para-hydroxycinnamic acid and cinnamic acid at alkaline pH
Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or phenylalanine are grown in the presence of either tyrosine ammonium lyase or phenylalanine ammonium lyase respectively where some part of the fermentati...
Saved in:
Main Authors | , , , , |
---|---|
Format | Patent |
Language | English |
Published |
23.08.2011
|
Online Access | Get full text |
Cover
Loading…
Abstract | Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or phenylalanine are grown in the presence of either tyrosine ammonium lyase or phenylalanine ammonium lyase respectively where some part of the fermentation is accomplished at alkaline pH. The process results in greater yields and higher rates of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) production as compared with fermentation exclusively at physiological pH. |
---|---|
AbstractList | Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or phenylalanine are grown in the presence of either tyrosine ammonium lyase or phenylalanine ammonium lyase respectively where some part of the fermentation is accomplished at alkaline pH. The process results in greater yields and higher rates of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) production as compared with fermentation exclusively at physiological pH. |
Author | Lowe, David J Sariaslani, Fateme Sima Patnaik, Ranjan Ben-Bassat, Arie Huang, Lisa L |
Author_xml | – sequence: 1 givenname: Arie surname: Ben-Bassat fullname: Ben-Bassat, Arie – sequence: 2 givenname: Fateme Sima surname: Sariaslani fullname: Sariaslani, Fateme Sima – sequence: 3 givenname: Lisa L surname: Huang fullname: Huang, Lisa L – sequence: 4 givenname: Ranjan surname: Patnaik fullname: Patnaik, Ranjan – sequence: 5 givenname: David J surname: Lowe fullname: Lowe, David J |
BookMark | eNqNjLsKAjEQRVNo4esf5gcWAkGxF2UbOxsrGfIwYeNMSEZw_14XrKyszuVwOUs1Iya_UNezl8iuQeAKEj2U6gtWlMQEHGDaXRxd5ddoExE-kgW0yQGSgx8jgHnAnOiT6ddqHjA3v_lypeB0vBz67tkKiidpt3vFCXqvtTHbnfnj8gaodDzD |
ContentType | Patent |
CorporateAuthor | E. I. du Pont de Nemours and Company |
CorporateAuthor_xml | – name: E. I. du Pont de Nemours and Company |
DBID | EFH |
DatabaseName | USPTO Issued Patents |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EFH name: USPTO Issued Patents url: http://www.uspto.gov/patft/index.html sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
ExternalDocumentID | 08003356 |
GroupedDBID | EFH |
ID | FETCH-uspatents_grants_080033563 |
IEDL.DBID | EFH |
IngestDate | Sun Mar 05 22:42:20 EST 2023 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-uspatents_grants_080033563 |
OpenAccessLink | https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8003356 |
ParticipantIDs | uspatents_grants_08003356 |
PatentNumber | 8003356 |
PublicationCentury | 2000 |
PublicationDate | 20110823 |
PublicationDateYYYYMMDD | 2011-08-23 |
PublicationDate_xml | – month: 08 year: 2011 text: 20110823 day: 23 |
PublicationDecade | 2010 |
PublicationYear | 2011 |
References | Gatenby et al. (6368837) 20020400 Jens Rosler et al., Maize Phenylalanine Ammonia-Lyase Has Tyrosine Ammonia-Lyase Activity, Plant Phys., vol. 113:175-179, 1997. S. Funfgelder et al., The Activity of Phenylatanine Ammonia-Lyase in Apple Leaves After Wounding, Acta Horticulture, vol. 381:474-478, 1994. Zilberstein, D. et al., "Escherichia coli intracellular pH, membrane potential, and cell growth," J. Bacteriol. (1984) 158 (1):246-252. Kyndt et al. FEBS lett 2002, 512, 240-244. Ben-Bassat et al. (2004/0229326) 20041100 Hye-Won Lim et al., Purification and Properties of Phenylalanine Ammonia-Lyase from Chinese Cabbage, Journal of Biochemistry and Molecular Biology, vol. 31(1):31-36, 1998. Qi et al. (2003/0079255) 20030400 Hitchcock , J. Gen. physiol. 1924, 747-757. A.A. Ameapuymrh et al.. Biotekhnologiya, vol. 2:24-28, 2000. Katsumata et al. (5484716) 19960100 Stancik et al. J. Bactrol. 2002, 184, 4246-4258. Kim et al. phytochem., 1996, vol. 43 pp. 351-357. Hye-Won Lim et al., Purification and Properties of Phenylalanine Ammonia-Lyase from Leaf Mustard, Mol. Cells., vol. 7(6):715-720, 1997. U.S. Appl. No. 10/824,237, filed Apr. 14, 2004, Ben-Bassat et al. Crocker et al. Microbiol. 2000, 146, 1295-1310. Wookey et al. J. bactrol. 1984, 166, 169-174. Hye-Won Lim et al., A Second Form of Phenylalanine Ammonia-Lyase from Leaf Mustard, Mol. Cells, vol. 8(3):343-349, 1998. Gale, E.F. and Epps, H.M.R., The effect of the pH of the medium during growth on the enzymatic activities of bacteria (Escherichia coli and Micrococcus lysodeikticus) and the biological significances of the changes produced, Biochemical J. (1942) 36(7-9):600-618. U.S. Appl. No. 10/138,970, filed May 3, 2002, Qi et al. Annamraju D. Sarma et al., Purification and characterization of UV-B Induced phenylalaine ammonia-lyase from rice seedings, Phytochemistry, vol. 50:729-737, 1999. Huang et al. (2004/0059103) 20040300 Ben-Bassat et al. (7378261) 20080500 Ben-Bassat et al. (2004/0248267) 20041200 Kim, Seong Hwan et al., Purification and Charcterization of Phenylalanine Ammonia-Lyase From Ustilago Maydis, Phytochemistry, Mar. 18, 1996, 351-357, vol. 43, No. 2, Elsevier Science Ltd., Great Britain. Jesus Jorrin et al., Purification and properties of phenylalanine ammonia-lyase from sunflower (Helianthus annus L.) hypocotyls, Biochimica et Biophysica Acta, vol. 964:73-82, 1988. Cochrane, Fiona C. et al., The Arabidopsis phenylalanine ammonia lyase gene family: kinetic characterization of the four PAL isoforms, Phytochemistry, Jun. 20, 2004, 1557-1564. vol. 65, Elsevier Ltd. Daniel S. Hodgins, Purification, Properties, and the Identification of Catalytically Essential Dehydroalanine, The Journal of Biological Chemistry, vol. 246(9):2977-2985, 1971. Tang (6521748) 20030200 Christopher T. Evans et al, Effect of glycerol, polyethylene glycol and glutaraldehyde on stability of phenylalanine ammonia-lyase activity in yeast, Journal of Industrial Microbiology, vol. 2:53-58, 1987. Christopher T. Evans et al., Novel stabilization of phenlalanine ammonia-lyase catalyst during bioconversion of trans-cinnamic acid to L-phenylalanine, Appl. Microbiol., Biotechnol., vol. 25:399-405, 1987. Christopher T. Evans et al., Biotransformation of trans-cinnamic acid to L-phenlalanine: optimization of reaction conditions using whole yeast cells, Enzyme Microb. Technol., vol. 9:417-421, 1987. |
References_xml | – year: 20030400 ident: 2003/0079255 contributor: fullname: Qi et al. – year: 20041200 ident: 2004/0248267 contributor: fullname: Ben-Bassat et al. – year: 20030200 ident: 6521748 contributor: fullname: Tang – year: 19960100 ident: 5484716 contributor: fullname: Katsumata et al. – year: 20040300 ident: 2004/0059103 contributor: fullname: Huang et al. – year: 20080500 ident: 7378261 contributor: fullname: Ben-Bassat et al. – year: 20041100 ident: 2004/0229326 contributor: fullname: Ben-Bassat et al. – year: 20020400 ident: 6368837 contributor: fullname: Gatenby et al. |
Score | 2.8238592 |
Snippet | Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or... |
SourceID | uspatents |
SourceType | Open Access Repository |
Title | Methods for the preparation of para-hydroxycinnamic acid and cinnamic acid at alkaline pH |
URI | https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8003356 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LSwMxEB7aIqgnRcX6Yg5eo1v30exZuixCpQeFeirZPLRYs8tuivjvzexqEUFvYQLDkJDMJHzfNwCXqZSRMYFmPDIFi5SRjEuVsESbkLig4yAmovD0Pskfo7t5PO9BvuHCvPljxCofS3O1bipXtuBKf713G8868WfSCLSkPvBuV6VQM2WuOXUli5M-9HlA0K5Jlu_CtnfhSzbrmh9JI9uDrVlr3YeetgfwNG2bNTfoy0T0ZRdWte6Et0uLpUEas5cPRbgSubRto3gUcqnQP_bxl8WhWL0KKhGxyg8Bs8nDbc42cSyea8K3LIKveMMjGPh3vj4G1KIw6UiEgSYNt7EWETGO1UinnPu0Hg9h-Kebk3_mTmHn-yP0JjyDgavX-txnUldctMv0CRQqgBM |
link.rule.ids | 230,309,786,808,891,64394 |
linkProvider | USPTO |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8QwEB7WVXycFBXX5xy8Rrv2se1Zt9THLj0orKeSNokuu6al7SL-ezOtLiLoLUxgGBKS70uY-QbgPMgyRylLMt9RKXOEypifCY95UtlUCzqwXCoUHo296Mm5m7iTDkTLWpg3c4xYYWKpLhZVUedNcqW53tuNZ634M2kEalIfeNfznItYqEufupK53gqsEsaSiv4wjLZgwzgxpE3X1Q_YCLdhLW6sO9CReheeR0275goNUURDvLAoZSu9nWvMFdKYvX4IyizJprppFY88mwo0z338ZamRz2ecSCIW0R5gOHy8jtgyjuSlpAyXxPqK2N6HrnnpywNAyVMV9LltSVJxG0juUM2x6MvA9w2wuz3o_enm8J-5M1iPb8Lk4XZ8fwSb37-iV_YxdOtyIU8MrNbpabNin4LFgw0 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Methods+for+the+preparation+of+para-hydroxycinnamic+acid+and+cinnamic+acid+at+alkaline+pH&rft.inventor=Ben-Bassat%2C+Arie&rft.inventor=Sariaslani%2C+Fateme+Sima&rft.inventor=Huang%2C+Lisa+L&rft.inventor=Patnaik%2C+Ranjan&rft.inventor=Lowe%2C+David+J&rft.number=8003356&rft.date=2011-08-23&rft.externalDBID=n%2Fa&rft.externalDocID=08003356 |