Methods for the preparation of para-hydroxycinnamic acid and cinnamic acid at alkaline pH

Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or phenylalanine are grown in the presence of either tyrosine ammonium lyase or phenylalanine ammonium lyase respectively where some part of the fermentati...

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Main Authors Ben-Bassat, Arie, Sariaslani, Fateme Sima, Huang, Lisa L, Patnaik, Ranjan, Lowe, David J
Format Patent
LanguageEnglish
Published 23.08.2011
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Summary:Methods for the microbial production of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) are provided. Microbes producing either tyrosine or phenylalanine are grown in the presence of either tyrosine ammonium lyase or phenylalanine ammonium lyase respectively where some part of the fermentation is accomplished at alkaline pH. The process results in greater yields and higher rates of para-hydroxycinnamic acid (pHCA) and cinnamic acid (CA) production as compared with fermentation exclusively at physiological pH.