Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase

The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated w...

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Main Authors Huang, Chung-Yang, Chen, Chia-Nan, Huang, Wei-Jan, Lin, Chia-Wei, Huang, Jing-Shi, Chi, Li-Ling, Chen, Ai-Ling, Lee, Chi-Yun, Huang, Yu-Chen
Format Patent
LanguageEnglish
Published 09.08.2011
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Summary:The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-cancer, anti-diabetic, and anti-neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Spinocerebellar Ataxias (SCA), and human spinal muscular atrophy (SMA).