Substituted pyridines and pyridazines with angiogenesis inhibiting activity

1 2 Substituted and pyridines and pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; Rand Rmay be def...

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Bibliographic Details
Main Authors Dumas, Jacques P, Boyer, Stephen J, Dixon, Julie A, Joe, Teddy K, Kluender, Harold C. E, Lee, Wendy, Nagarathnam, Dhanapalan, Sibley, Robert N, Su, Ning
Format Patent
LanguageEnglish
Published 12.07.2011
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Summary:1 2 Substituted and pyridines and pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is phenyl or a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; Rand Rmay be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.