Caspase inhibitors and uses thereof

1 222 22221 3332332333 1-6 1-4 1-4 This invention provides novel caspase inhibitors of formula I: wherein Ris hydrogen, CHN, R, or -CHY; R is an aliphatic group, an aryl group, an aralkyl group, a heterocyclyl group, or a heterocyclylalkyl group; Y is an electronegative leaving group; Ris COH, CHCOH...

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Bibliographic Details
Main Authors Charrier, Jean-Damien, Brenchley, Guy
Format Patent
LanguageEnglish
Published 28.06.2011
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Summary:1 222 22221 3332332333 1-6 1-4 1-4 This invention provides novel caspase inhibitors of formula I: wherein Ris hydrogen, CHN, R, or -CHY; R is an aliphatic group, an aryl group, an aralkyl group, a heterocyclyl group, or a heterocyclylalkyl group; Y is an electronegative leaving group; Ris COH, CHCOH, or esters, amides or isosteres thereof; X-Xis N(R)-C(R), C(R)-C(R), C(R)-N, N═C, C(R)═C, C(═O)-N, or C(═O)-C(R); each Ris independently selected from hydrogen or Caliphatic; Ring C is a fused aryl ring; n is 0, 1 or 2; and each methylene carbon in Ring A is optionally and independently substituted by ═O, or one or more halogen, Calkyl, or Calkoxy. The compounds are useful for treating caspase-mediated diseases.