Bifunctional compound containing amino group and diaminedithiol ligand and manufacturing method thereof

2222 22 A bifunctional compound containing an amino group and diaminedithiol ligand and a manufacturing method thereof are revealed, the bifunctional compound includes at least one amino group and a diaminedithiol (NS) ligand. The amino groups is for reacting with compounds containing carboxylic aci...

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Bibliographic Details
Main Authors Liu, Show-Wen, Lin, Cheng-Hsien, Lin, Tsyh-Lang, Hsu, Cheng-Fang
Format Patent
LanguageEnglish
Published 21.06.2011
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Summary:2222 22 A bifunctional compound containing an amino group and diaminedithiol ligand and a manufacturing method thereof are revealed, the bifunctional compound includes at least one amino group and a diaminedithiol (NS) ligand. The amino groups is for reacting with compounds containing carboxylic acids or halogens while the NSligand binds with technetium or rhenium so as to form an anion complex. The thiol group in the NSligand is protected by a protecting group for prevention of oxidation and easy storage. This protecting group is released easily during complex reactions. Due to the bifunctional property, the compound is applied to preparation of radiopharmaceuticals such as imaging agents and targeted agents.