Modified leukotoxin gene and protein

Mannheimia haemolyticaMannheimia haemolytica The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin...

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Bibliographic Details
Main Authors Lo, Reggie Y. C, Shewen, Patricia E, Lee, Raymond W. H, Hodgins, Doug, Strommer, Judith N
Format Patent
LanguageEnglish
Published 26.04.2011
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Summary:Mannheimia haemolyticaMannheimia haemolytica The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably from . The modified leukotoxin proteins are useful in vaccine compositions effective against in animals.