Multiparticulate crystalline drug compositions having controlled release profiles

A multiparticulate for controlled release of a drug comprises crystalline drug, a glyceride having at least one alkylate substituent of at least 16 carbon atoms, and a poloxamer, wherein at least 70 wt % of the drug in the multiparticulate is crystalline.

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Bibliographic Details
Main Authors Appel, Leah E, Ray, Roderick J, Lyon, David K, West, James B, McCray, Scott B, Crew, Marshall D, Friesen, Dwayne T, Herbig, Scott M, Lo, Julian B
Format Patent
LanguageEnglish
Published 15.02.2011
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Summary:A multiparticulate for controlled release of a drug comprises crystalline drug, a glyceride having at least one alkylate substituent of at least 16 carbon atoms, and a poloxamer, wherein at least 70 wt % of the drug in the multiparticulate is crystalline.