Attenuated chimeric flavivirus bearing attenuated Japanese encephalitis virus gene as backbone

A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s)...

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Main Authors Kouichi, Morita, Nabeshima, Takeshi, Miyake, Shinichi, Onishi, Toshiyuki, Fuke, Isao, Ishikawa, Toyokazu, Goda, Hideo, Ishibashi, Masahide, Takahashi, Michiaki
Format Patent
LanguageEnglish
Published 06.07.2010
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Summary:A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.