6-carboaryl-oxy-pyrazin-2-yl-carboaryl-amines and compositions comprising said compounds

P3 11116-14P2 P5 6-14 P6 The present invention pertains to certain 6-carboaryloxy-pyrazin-2-yl-carboaryl-amines of the following formula, and pharmaceutically acceptable salts thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit cell proliferation, treat cancer, etc., wherein Q is...

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Bibliographic Details
Main Authors Springer, Caroline Joy, Niculescu-Duvaz, Ion, Vela, Esteban Roman, Gill, Adrian Liam, Taylor, Richard David, Marais, Richard Malcolm
Format Patent
LanguageEnglish
Published 15.06.2010
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Summary:P3 11116-14P2 P5 6-14 P6 The present invention pertains to certain 6-carboaryloxy-pyrazin-2-yl-carboaryl-amines of the following formula, and pharmaceutically acceptable salts thereof, which, inter alia, inhibit RAF (e.g., B-RAF) activity, inhibit cell proliferation, treat cancer, etc., wherein Q is independently -N═; Ris independently a group of the formula -J-L-Z; -JL-Z is independently -NH-Z; Z is independently Ccarboaryl and is independently unsubstituted or substituted; Ris independently -H; Ris independently a group of the formula -W-Y; W is independently -O-; Y is independently Ccarboaryl and is independently unsubstituted or substituted; and Ris independently -H. The present invention also pertains to pharmaceutical compositions comprising such compounds.