Mitotic kinesin inhibitors

The present invention relates to N-substituted benzylic aniline derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compo...

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Bibliographic Details
Main Authors Garbaccio, Robert M, Olson, Christy M, Tasber, Edward S, Torrent, Maricel
Format Patent
LanguageEnglish
Published 27.10.2009
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Summary:The present invention relates to N-substituted benzylic aniline derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.