Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1

7 7 1-33-8Compounds of the formula wherein: Y′ is O or S, W′ is optionally substituted, Z′ is selected from the group consisting of wherein Q′ is ORand Ris CalkyleneCheterocycloalkyl useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed....

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Main Authors Kesicki, Edward A, Gaudino, John Joseph, Cook, Adam Wade, Cowen, Scott Douglas, Burgess, Laurence Edward
Format Patent
LanguageEnglish
Published 27.10.2009
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Abstract 7 7 1-33-8Compounds of the formula wherein: Y′ is O or S, W′ is optionally substituted, Z′ is selected from the group consisting of wherein Q′ is ORand Ris CalkyleneCheterocycloalkyl useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
AbstractList 7 7 1-33-8Compounds of the formula wherein: Y′ is O or S, W′ is optionally substituted, Z′ is selected from the group consisting of wherein Q′ is ORand Ris CalkyleneCheterocycloalkyl useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
Author Cook, Adam Wade
Gaudino, John Joseph
Kesicki, Edward A
Cowen, Scott Douglas
Burgess, Laurence Edward
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Snippet 7 7 1-33-8Compounds of the formula wherein: Y′ is O or S, W′ is optionally substituted, Z′ is selected from the group consisting of wherein Q′ is ORand Ris...
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Title Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1
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