Urea or thiourea substituted 1,4-pyrazine compounds useful as anti-cancer agents and for inhibiting Chk1

7 7 1-33-8Compounds of the formula wherein: Y′ is O or S, W′ is optionally substituted, Z′ is selected from the group consisting of wherein Q′ is ORand Ris CalkyleneCheterocycloalkyl useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed....

Full description

Saved in:
Bibliographic Details
Main Authors Kesicki, Edward A, Gaudino, John Joseph, Cook, Adam Wade, Cowen, Scott Douglas, Burgess, Laurence Edward
Format Patent
LanguageEnglish
Published 27.10.2009
Online AccessGet full text

Cover

More Information
Summary:7 7 1-33-8Compounds of the formula wherein: Y′ is O or S, W′ is optionally substituted, Z′ is selected from the group consisting of wherein Q′ is ORand Ris CalkyleneCheterocycloalkyl useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.